MLB Prop Bets for 2025: Pitcher Wins, Home Runs & More

Looking for a betting edge in the 2025 MLB season? Here are some intriguing player props worth considering as we approach opening day.

Zack Wheeler (+1000) looks primed to lead MLB in wins this year. The Phillies ace won 16 games last season despite getting minimal run support in half his starts. In 16 of his 32 outings, Philadelphia scored three or fewer runs. Compare that to teammate Aaron Nola, who faced that situation far less frequently.

Wheeler’s a workhorse by today’s standards and plays for a team that should rack up plenty of victories. I’m predicting he’ll hit the 20-win mark this season.

For strikeouts, I’m passing on favorite Paul Skenes (+400) and going with Cole Ragans (+2500).

Ragans finished just five strikeouts off the MLB lead last year with 223 K’s in 185+ innings. With a natural workload increase, he could approach 250 strikeouts this season. The Pirates might limit Skenes’ innings, especially if they fall out of contention.

This is my favorite prop bet of the entire season.

Raisel Iglesias (+1100) is my pick to lead baseball in saves. While Emmanuel Clase and Ryan Helsley topped the category last year (Helsley led with 49), I see Iglesias breaking through. He’s recorded 33-34 saves in recent seasons, but faces zero competition in Atlanta’s bullpen. With the Braves likely winning the NL East, save opportunities should be plentiful.

Is this partly gut feeling? Sure. But sometimes you’ve got to trust your instincts.

Pete Alonso (+1400) is positioned perfectly to lead MLB in RBIs. He drove in 131 runs in 2022 and 120 in 2019 before dipping to 88 last season. Now he’s hitting behind Francisco Lindor and Juan Soto, who should be on base constantly. With solid protection behind him in the lineup, Alonso should see plenty of good pitches with runners aboard.

For home runs, Matt Olson at +3000 offers tremendous value. He’s the 10th name on the odds list despite leading MLB with 54 homers in 2023. Olson is incredibly durable, playing all 162 games in each of the last three seasons. After a down 2024, he’s due for a power rebound.

The chalk picks here are Aaron Judge (+360) and Shohei Ohtani (+650), but at those odds, Olson is worth a shot.

Bobby Witt Jr. (+550) is the favorite to lead in hits, and for good reason. He topped MLB with 211 hits last season while batting .332. At just 24 years old, hitting second in Kansas City’s lineup and not walking much, he’ll get plenty of opportunities to pile up hits again.

For doubles, Alex Bregman (+1600) is an interesting play. He led MLB with 51 doubles back in 2018, and his move to Fenway Park could boost his numbers. As a pull hitter accustomed to Houston’s Crawford Boxes, some of his would-be homers will likely become doubles off the Green Monster. Last year’s metrics showed he would’ve hit 31 homers in Houston but only 23 in Boston – those missing eight would likely be doubles in Fenway.

Finally, Pete Crow-Armstrong (+215) to steal 40+ bases offers nice value. PCA swiped 27 bags in 30 attempts last year despite a mediocre .286 on-base percentage. If he can maintain the improved hitting he showed late last season (.289/.336/.469 in his final 57 games), he’ll be an everyday player with a great shot at 40+ steals.

For stolen base leader, Elly De La Cruz is the obvious choice, but at -120 odds, I’d rather target PCA’s 40+ steals at a better price.